Title: Version 9.4 SAS System Output
Author: SAS Version 9.4

TEDDY
Number of Case-Control Subjects with Omics Data by Laboratory and Analyte
Data Current as of April 30, 2024

| Persistent Confirmed Islet Autoimmunity | Type 1 Diabetes
Laboratory | Analyte | Case | Control | Case + Control | Case | Control | Case + Control
Dietary Biomarkers | Ascorbic Acid | 381 | 1097 | 1478 | 105 | 327 | 432
| Carotenoids | 384 | 1102 | 1486 | 106 | 331 | 437
| Cholesterol | 384 | 1103 | 1487 | 106 | 331 | 437
| Fatty Acids | 401 | 1185 | 1586 | 111 | 335 | 446
| Retinol | 384 | 1098 | 1482 | 106 | 331 | 437
| Tocopherols | 384 | 1103 | 1487 | 106 | 331 | 437
| Vitamin D | 410 | 1218 | 1628 | 113 | 341 | 454
Exome | TEDDY-T1DExome Array | 368 | 1155 | 1523 | 93 | 319 | 412
Gene Expression | Microarray | 175 | 202 | 377 | 63 | 77 | 140
Metabolomics | Lipidomics | 414 | 1234 | 1648 | 113 | 341 | 454
| Primary Metabolites | 414 | 1234 | 1648 | 113 | 341 | 454
Microbiome | Nasal Swabs - 16S | 175 | 191 | 366 | 16 | 36 | 52
| Nasal Swabs - Cultured Virome | 175 | 191 | 366 | 16 | 36 | 52
| Nasal Swabs - ITS | 175 | 191 | 366 | 16 | 36 | 52
| Nasal Swabs - Primary Virome | 175 | 191 | 366 | 16 | 36 | 52
| Nasal Swabs - WGS | 148 | 166 | 314 | 14 | 31 | 45
| Plasma - Cultured Virome | 415 | 487 | 902 | 113 | 156 | 269
| Plasma - WGS/Virome | 405 | 475 | 880 | 105 | 147 | 252
| Stool - 16S | 410 | 473 | 883 | 113 | 155 | 268
| Stool - Cultured Virome | 404 | 466 | 870 | 112 | 153 | 265
| Stool - Deep WGS | 82 | 80 | 162 | 21 | 7 | 28
| Stool - ITS | 396 | 455 | 851 | 107 | 146 | 253
| Stool - Primary Virome | 408 | 471 | 879 | 112 | 154 | 266
| Stool - WGS | 401 | 457 | 858 | 110 | 151 | 261
RNA Sequencing | RNA-Seq | 408 | 468 | 876 | 112 | 155 | 267
SNP | Immunochip | 383 | 1158 | 1541 | 110 | 317 | 427
Whole Genome Sequencing | WGS | 345 | 472 | 817 | 81 | 139 | 220

SNP data is available for the full TEDDY cohort